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p(HGNC:CHRNB2)

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Entity

Name
CHRNB2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 12

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

In-Edges 22

complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) View Subject | View Object

For example, local infusion of the α7 antagonist, methyllycaconitine (MLA), or the β2∗ antagonist, dihydro-β-erythroidine (DHβE), into the basolateral amygdala, the ventral hippocampus, or the dorsal hippocampus impairs the working memory of rats seeking food reward within a 16-arm radial maze (146–148). PubMed:17009926

Appears in Networks:
Annotations
MeSH
Amygdala
MeSH
Hippocampus

p(FPLX:CHRN) hasMember p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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p(GFAM:"Cholinergic receptors nicotinic subunits") hasMember p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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p(HGNC:DNM1) association p(HGNC:CHRNB2) View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

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Annotations
Text Location
Review

p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

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Annotations
Text Location
Review

p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

complex(p(HGNC:CHRNB2), p(HGNC:RIC3)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB2), p(HGNC:CHRNB4)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(a(MESH:"Dihydro-beta-Erythroidine"), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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Out-Edges 7

act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNB2) hasVariant p(HGNC:CHRNB2, var("?")) View Subject | View Object

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p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:CHRNB2) association p(HGNC:DNM1) View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") View Subject | View Object

The cytoplasmic domain of the alpha4 nAChR subunit binds the scaffold protein 14-3-3η and the Ca2+ sensor visinin-like protein 1 (ReF. 69), and the beta2 subunit interacts with several cytoskeletal proteins, such as tubulin, dynamin and clathrin, and with G protein systems that are involved in intracellular signalling pathways70. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) View Subject | View Object

in α4- and β2-knockout mice, the responses of raphe neurons to nicotine is abolished, together with nicotine-elicited antinociception228, and α4-hypersensitive knock-in mice show nicotine hypersensitivity in the supraspinal control (hot-plate assay), but not in the spinal control (tail flick assay)229. PubMed:19721446

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Annotations
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.