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complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2))

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Components

Appears in Networks 2

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

In-Edges 1

p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) View Subject | View Object

For example, while the alpha7 nAChR is primarily a homomeric receptor in neurons (127), combinations of alpha7 nAChR subunits with alpha5, beta2, or beta3 nAChR subunits have been reported to form functional heteromeric receptors in some systems (240, 360, 515). PubMed:19126755

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Out-Edges 5

complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNA7) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) View Subject | View Object

For example, while the alpha7 nAChR is primarily a homomeric receptor in neurons (127), combinations of alpha7 nAChR subunits with alpha5, beta2, or beta3 nAChR subunits have been reported to form functional heteromeric receptors in some systems (240, 360, 515). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNB2) View Subject | View Object

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complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") View Subject | View Object

In addition to the alpha4beta2 subtype, it was demonstrated that the alpha7 subunit is able to coassemble with the beta2 subunit to form a heteropentameric receptor PubMed:25514383

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complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) View Subject | View Object

Under these experimental conditions, alpha7 and beta2 are able to co-assemble into a functional receptor that localizes at the cell surface PubMed:25514383

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.