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bp(GO:"depolarization of postsynaptic membrane")

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Entity

Name
depolarization of postsynaptic membrane
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 3

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1

In-Edges 3

bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

In receptors harboring the gamma subunit, agonist-induced receptor activation results in a long-lasting open channel time. The large agonist-induced current in turn leads to local intermittent depolarization and adjustments to protein-protein interactions that favor receptor clustering. As the depolarization increases, transcription of the epsilon subunit is increased dramatically (183). PubMed:19126755

Appears in Networks:
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Text Location
Review

act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

Out-Edges 5

bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) View Subject | View Object

In receptors harboring the gamma subunit, agonist-induced receptor activation results in a long-lasting open channel time. The large agonist-induced current in turn leads to local intermittent depolarization and adjustments to protein-protein interactions that favor receptor clustering. As the depolarization increases, transcription of the epsilon subunit is increased dramatically (183). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) View Subject | View Object

If there is intense stimulation of all three nAChRs, the resulting depolarization can trigger activation of voltage- gated Ca2+ channels (VGCC), which in turn would activate the calcineurin pathway and prevent CREB activation. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

The combination of enhanced glutamatergic release and strong postsynaptic response produces LTP of the glutamatergic afferents. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
glutamatergic neuron

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.