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bp(GO:"regulation of action potential firing rate")

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Entity

Name
regulation of action potential firing rate
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1

In-Edges 6

a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

In most cases, the exogenously applied ACh caused action potential firing by the GABA neuron that consequently regulated the activity of nearby pyramidal neurons (100, 103). PubMed:17009926

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Activation of nAChRs on distal apical dendrites depolarizes the cell and promotes action potential firing PubMed:17009926

Appears in Networks:
Annotations
MeSH
Dendrites
MeSH
Neocortex

p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") View Subject | View Object

Acting through these excitatory and inhibitory inputs and nAChRs located on the DA neurons, nicotinic receptors influence the firing modes and firing frequency of DA neurons (119, 121). PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron
MeSH
Dendrites
MeSH
Neocortex

p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

The nicotine initially activates nAChRs on DA neurons, causing an increase in burst firing and overall firing rate (88, 121, 123, 124, 134). PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

Out-Edges 1

bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) View Subject | View Object

Acting through these excitatory and inhibitory inputs and nAChRs located on the DA neurons, nicotinic receptors influence the firing modes and firing frequency of DA neurons (119, 121). PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron
MeSH
Dendrites
MeSH
Neocortex

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.