Name
Post-Synaptic Density
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) View Subject | View Object

We observed a similar LTPinduced increase in tau content within the PSD-enriched fraction from CA1 synaptosomes (29.86 +-4.86 to 70.15 +- 4.86, **p = 0.0011; Fig. 3B). As expected, actin and GluA1 were also increased, strengthening the idea that tau is involved in synaptic reorganization processes necessary for synaptic plasticity PubMed:24760868

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.