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path(HM:"Heme cytotoxicity")

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Entity

Name
Heme cytotoxicity
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

p(HGNC:ALB, var("tyr")) decreases path(HM:"Heme cytotoxicity") View Subject | View Object

This result suggested that tyrosine residues of BSA may play an important role in heme detoxification. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Discussion

p(HGNC:FTH1) decreases path(HM:"Heme cytotoxicity") View Subject | View Object

Importantly, increased expression of FtH also protects different cell types from the cytotoxic effects of heme, TNF or heme and TNF (Balla et al., 1992; Berberat et al., 2003; Cozzi et al., 2003; Gozzelino et al., 2012). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

p(RGD:Alb) decreases path(HM:"Heme cytotoxicity") View Subject | View Object

For this reason, it has been considered as a therapeutic tool to counteract heme toxic effects in severe hemolytic diseases, and the usefulness of SA therapy has already been demonstrated in a rat model of acute intracerebral hematoma [2, 9]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Introduction

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.