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complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1))

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Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

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complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) hasComponent a(MESHC:"pro-nerve growth factor, human") View Subject | View Object

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complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) hasComponent p(HGNC:NTRK1) View Subject | View Object

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complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") View Subject | View Object

In this regard, immunoblotting studies demonstrated that proNGF is the predominant form of NGF present in the cortex of aged cognitively intact humans [60]. ProNGF levels are increased in the cortex of subjects diagnosed with MCI or mild AD compared to those with NCI [61]. The biological consequences of proNGF are controversial, as is the function of its accumulation in the cortex during the prodromal stages of AD. Emerging literature suggests that recombinant proNGF binds TrkA and promotes neuronal survival and neurite outgrowth similar to mature NGF, but is approximately fivefold less active than the mature NGF peptide [62,63]. PubMed:18986241

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MeSH
Cerebral Cortex
MeSH
Cognitive Dysfunction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.