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a(CHEBI:cycloheximide)

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Entity

Name
cycloheximide
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 3

Activation and regulation of the inflammasomes v1.0.0

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.0

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1

In-Edges 0

Out-Edges 3

a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") View Subject | View Object

In the presence of the translation inhibitor cycloheximide, TRIF signalling that is downstream of TLR3 or TLR4 leads to pro-IL-1β processing by caspase 8 (REF. 55). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

a(CHEBI:cycloheximide) decreases bp(GO:translation) View Subject | View Object

Conversely, treatment with protein translation inhibitors, cycloheximide or anisomycin, alone (Fig. S8A and B) almost completely abrogated MAPT missorting (schematic in Fig. 2E). These results suggest that the dendritic MAPT is locally generated. PubMed:30145931

Appears in Networks:

a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) View Subject | View Object

Conversely, treatment with protein translation inhibitors, cycloheximide or anisomycin, alone (Fig. S8A and B) almost completely abrogated MAPT missorting (schematic in Fig. 2E). These results suggest that the dendritic MAPT is locally generated. PubMed:30145931

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.