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r(MGI:Slc40a1)

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Entity

Name
Slc40a1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:heme) positiveCorrelation r(MGI:Slc40a1) View Subject | View Object

Our in vivo observations could be recapitulated in isolated macrophages, which upon stimulation with heme (25 lM; 16 h) demonstrated increased ferroportin mRNA and protein expression (Fig. 4A, B) and a significant decrease in the intracellular iron pool (2.2-fold; p < 0.01) (Fig. 4C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:lipopolysaccharide) negativeCorrelation r(MGI:Slc40a1) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

complex(a(CHEBI:acetylcysteine), a(CHEBI:heme)) decreases r(MGI:Slc40a1) View Subject | View Object

We showed that increase in ferroportin mRNA and protein expression by heme was effectively prevented in mice receiving combined treatment of NAC and heme (Fig. 8D, E). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

p(MGI:Hpx) decreases r(MGI:Slc40a1) View Subject | View Object

Moreover, the mRNA levels of Fpn and Flvcr1a were increased in Hx-/- mice, whereas those of the iron importers Divalent Metal Transporter 1 (Dmt1) and Tfr1 were decreased (see Figure 4 in [37]). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

Out-Edges 2

r(MGI:Slc40a1) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Our in vivo observations could be recapitulated in isolated macrophages, which upon stimulation with heme (25 lM; 16 h) demonstrated increased ferroportin mRNA and protein expression (Fig. 4A, B) and a significant decrease in the intracellular iron pool (2.2-fold; p < 0.01) (Fig. 4C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

r(MGI:Slc40a1) negativeCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.