1. Catalog
  2. Nodes
  3. path(MESH:"Oxidative Stress")

path(MESH:"Oxidative Stress")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Oxidative Stress
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 4

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 6

act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") View Subject | View Object

Activation of M1 mAChR also protects against apoptotic factors in human neuroblastoma SH-SY5Y cells, such as DNA damage, oxidative stress, caspase activation, and mitochondrial impairment[83]. In addition, apoptosis induced by serum deprivation is blocked by M1 mAChR activation in a phosphoinositide 3-kinase- and MAPK/ERKindependent manner PubMed:24590577

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

a(CHEBI:"alpha-tocopherol") decreases path(MESH:"Oxidative Stress") View Subject | View Object

Oxidative stress and A expression were suppressed with -tocopherol in mouse model. PubMed:29179999

Appears in Networks:

a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") View Subject | View Object

Xanthoceraside alleviated the A 25-35-stimulated spatial memory deficiencies and oxidative stress in mouse models [246]. PubMed:29179999

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") View Subject | View Object

Beneficial effects of 4-O-methylhonokinol on memory were observed by the reduction of Aaggregation in A 1-42-injected mice and memory-impaired mice with its anti-oxidative and anti-inflammatory qualities [141–143]. PubMed:29179999

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") View Subject | View Object

Nicorandil, ATP-sensitive potassium channel opener, reduced apo- ptosis and decreased oxidative stress, downregulated APP695 mRNA and APP695 protein expression, also reduced Aβ 42 levels in the medium [90]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

Out-Edges 1

path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.