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complex(p(HGNC:CASP8), p(HGNC:MALT1))

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Components

Appears in Networks 1

Activation and regulation of the inflammasomes v1.0.0

In-Edges 1

act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) View Subject | View Object

For example, following sensing of fungal components by the PRR dectin 1 that is expressed on human dendritic cells, signalling via the kinase SYK leads to the formation of a complex that is composed of caspase 8 and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); this complex binds to ASC, which possibly recruits cleavage substrates53. The MALT1-ASC-caspase 8 complex directly mediates IL-1β maturation53. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Out-Edges 3

complex(p(HGNC:CASP8), p(HGNC:MALT1)) hasComponent p(HGNC:CASP8) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP8), p(HGNC:MALT1)) hasComponent p(HGNC:MALT1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) View Subject | View Object

For example, following sensing of fungal components by the PRR dectin 1 that is expressed on human dendritic cells, signalling via the kinase SYK leads to the formation of a complex that is composed of caspase 8 and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); this complex binds to ASC, which possibly recruits cleavage substrates53. The MALT1-ASC-caspase 8 complex directly mediates IL-1β maturation53. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.