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p(HGNC:CASP8)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CASP8
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Activation and regulation of the inflammasomes v1.0.0

In-Edges 7

complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) hasComponent p(HGNC:CASP8) View Subject | View Object

Appears in Networks:

bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) View Subject | View Object

In the presence of the translation inhibitor cycloheximide, TRIF signalling that is downstream of TLR3 or TLR4 leads to pro-IL-1β processing by caspase 8 (REF. 55). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) View Subject | View Object

Furthermore, in response to genotoxic stress, the ripoptosome assembles and activates caspase 8. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

complex(GO:ripoptosome) hasComponent p(HGNC:CASP8) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP8), p(HGNC:MALT1)) hasComponent p(HGNC:CASP8) View Subject | View Object

Appears in Networks:

act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) View Subject | View Object

In addition, it was recently shown that CD95 signalling mediates IL-1β and IL-18 processing through the activation of caspase 8 (REF. 60) (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tumor necrosis factor subgraph

act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) View Subject | View Object

The formation of this complex activates RIP3, which is necessary for the cleavage of pro-IL-1β by both the NLRP3-caspase 1 and the caspase 8 pathways56 (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Out-Edges 4

p(HGNC:CASP8) increases act(p(HGNC:IL1B)) View Subject | View Object

One additional factor that can mediate IL-1β processing and activation is caspase 8 (FIG. 1) PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) View Subject | View Object

In the presence of the translation inhibitor cycloheximide, TRIF signalling that is downstream of TLR3 or TLR4 leads to pro-IL-1β processing by caspase 8 (REF. 55). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) View Subject | View Object

In addition, it was recently shown that CD95 signalling mediates IL-1β and IL-18 processing through the activation of caspase 8 (REF. 60) (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tumor necrosis factor subgraph

act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) View Subject | View Object

In addition, it was recently shown that CD95 signalling mediates IL-1β and IL-18 processing through the activation of caspase 8 (REF. 60) (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tumor necrosis factor subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.