p(MGI:Casp1)
Western blotting results showed that the p10 active form of caspase-1 was detected in macrophages incubated with heme for 12 h. PubMed:24464629
These results suggest that heme induces maturation and secretion of IL-1b in macrophages through activating caspase-1 (Fig. 2a). PubMed:24464629
The results showed that enforced HO-1 could efficiently decline the heme level in the lysates of ligated kidneys, and inhibit kidney inflammation characterized by down-regulation of NLRP3-Caspase- 1-IL-1b axis. PubMed:24464629
These results suggest that heme induced activation of NLRP3-Caspase-1-IL-1b axis is involved in kidney inflammation in mice UUO model and that heme serves as a dangerous factor participates in this process. PubMed:24464629
In support, knockout of NLRP3 and caspase-1 have been shown to suppress amyloidogenesis and neuropathology, and improve cognition in AD transgenic mice (Heneka et al., 2013) PubMed:24561250
In support, knockout of NLRP3 and caspase-1 have been shown to suppress amyloidogenesis and neuropathology, and improve cognition in AD transgenic mice (Heneka et al., 2013) PubMed:24561250
In support, knockout of NLRP3 and caspase-1 have been shown to suppress amyloidogenesis and neuropathology, and improve cognition in AD transgenic mice (Heneka et al., 2013) PubMed:24561250
Western blotting results showed that the p10 active form of caspase-1 was detected in macrophages incubated with heme for 12 h. PubMed:24464629
These results suggest that heme induces maturation and secretion of IL-1b in macrophages through activating caspase-1 (Fig. 2a). PubMed:24464629
These results suggest that heme induces maturation and secretion of IL-1b in macrophages through activating caspase-1 (Fig. 2a). PubMed:24464629
These results suggest that heme induced activation of NLRP3-Caspase-1-IL-1b axis is involved in kidney inflammation in mice UUO model and that heme serves as a dangerous factor participates in this process. PubMed:24464629
The results showed that enforced HO-1 could efficiently decline the heme level in the lysates of ligated kidneys, and inhibit kidney inflammation characterized by down-regulation of NLRP3-Caspase- 1-IL-1b axis. PubMed:24464629
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.