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p(HGNC:SLC18A2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SLC18A2
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc-names.belns

Appears in Networks 1

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 4

a(CHEBI:dopamine) association p(HGNC:SLC18A2) View Subject | View Object

In fact, METH produces a massive increase of endogenous intra-cytosolic DA levels by inhibiting and reverting the direction of the vesicular monoamine transporter type 2 (VMAT-2), thus disrupting the physiological storage of DA PubMed:30061532

Appears in Networks:

a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC18A2)) View Subject | View Object

In fact, METH produces a massive increase of endogenous intra-cytosolic DA levels by inhibiting and reverting the direction of the vesicular monoamine transporter type 2 (VMAT-2), thus disrupting the physiological storage of DA PubMed:30061532

Appears in Networks:

a(CHEBI:methamphetamine) negativeCorrelation p(HGNC:SLC18A2) View Subject | View Object

A reduction in VMAT-2 gene expression and protein levels in DA neurons occurs in both METH models and schizophrenic patients, marking quite impressively the overlap between these disorders PubMed:30061532

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron

path(MESH:Schizophrenia) negativeCorrelation p(HGNC:SLC18A2) View Subject | View Object

A reduction in VMAT-2 gene expression and protein levels in DA neurons occurs in both METH models and schizophrenic patients, marking quite impressively the overlap between these disorders PubMed:30061532

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron

Out-Edges 3

p(HGNC:SLC18A2) association a(CHEBI:dopamine) View Subject | View Object

In fact, METH produces a massive increase of endogenous intra-cytosolic DA levels by inhibiting and reverting the direction of the vesicular monoamine transporter type 2 (VMAT-2), thus disrupting the physiological storage of DA PubMed:30061532

Appears in Networks:

p(HGNC:SLC18A2) negativeCorrelation path(MESH:Schizophrenia) View Subject | View Object

A reduction in VMAT-2 gene expression and protein levels in DA neurons occurs in both METH models and schizophrenic patients, marking quite impressively the overlap between these disorders PubMed:30061532

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron

p(HGNC:SLC18A2) negativeCorrelation a(CHEBI:methamphetamine) View Subject | View Object

A reduction in VMAT-2 gene expression and protein levels in DA neurons occurs in both METH models and schizophrenic patients, marking quite impressively the overlap between these disorders PubMed:30061532

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.