p(HGNC:PPP2R2A)

Entity

Name

PPP2R2A

Namespace

hgnc

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

In neurons, B55 α and B55 β are localized in the cytoplasm, whereas B55 γ is localized in the cytoskeletal fraction. PubMed:23454242

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Within the brain, ACB55
(B55
) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55
, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

In neurons, B55 α and B55 β are localized in the cytoplasm, whereas B55 γ is localized in the cytoskeletal fraction. PubMed:23454242

It has been shown in yeast that CDC55 (B55 in human) is essential for cytokinesis. PubMed:23454242

Within the brain, ACB55
(B55
) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55
, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660