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a(MESH:Brain)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Brain
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 7

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

PP2A and Alzheimer Disease v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 12

act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) View Subject | View Object

Because excess activation of nAChRs damages neuronal health and brain function, organisms have a clear need to restrict the degree of nAChR activation PubMed:21482353

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act(p(HGNC:NPEPPS)) association a(MESH:Brain) View Subject | View Object

Aminopeptidases are a group of enzymes that cleave from the N-terminal end of a protein. The family includes alanyl, arginyl, and glutamyl peptidases. Puromycin sensitive aminopeptidase (PSA) is an alanyl peptidase that is responsible for s90% of the aminopeptidase activity in the brain(10). PubMed:24027553

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Annotations
Text Location
Review

path(MESH:"Alzheimer Disease") decreases a(MESH:Brain) View Subject | View Object

Recent advances now enable several AD-related brain changes to be detected in vivo: 18F-FDG-PET detects decreases in glucose metabolism,45,46 and MRI detects brain atrophy, as well as diffusion and perfu- sion abnormalities, which are most prominent in the vul- nerable hippocampal formation and cortical regions. PubMed:26195256

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p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) View Subject | View Object

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p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) View Subject | View Object

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p(HGNC:PPP2R2A) association a(MESH:Brain) View Subject | View Object

Within the brain, ACB55 (B55) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

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p(HGNC:MAPT) increases act(a(MESH:Brain)) View Subject | View Object

Although tau function can be partly compensated by other, redundant microtubule-associated proteins (for example, MAP1A), the behavioural impairments observed in aged (~12‑month-old) tau-knockout mice indicate that tau is necessary for normal neuronal and brain function. PubMed:26631930

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Out-Edges 3

act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) View Subject | View Object

Because excess activation of nAChRs damages neuronal health and brain function, organisms have a clear need to restrict the degree of nAChR activation PubMed:21482353

Appears in Networks:

a(MESH:Brain) association act(p(HGNC:NPEPPS)) View Subject | View Object

Aminopeptidases are a group of enzymes that cleave from the N-terminal end of a protein. The family includes alanyl, arginyl, and glutamyl peptidases. Puromycin sensitive aminopeptidase (PSA) is an alanyl peptidase that is responsible for s90% of the aminopeptidase activity in the brain(10). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Brain) association p(HGNC:PPP2R2A) View Subject | View Object

Within the brain, ACB55 (B55) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.