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p(MGI:Prdx2, pmod(Ox))

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Entity

Name
Prdx2
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"carbon monoxide") positiveCorrelation p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Figure 5C shows that pretreatment of human RBC stored for 35 days with CO, or CO-added 5 min after H2O2, significantly accelerated Prx-2 reduction from the dimer to monomer (by *35% relative to control at 20 min). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(CHEBI:"carbon monoxide") decreases p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Presaturation of RBC with CO affected neither initial H2O2- dependent Prx-2 oxidation nor Prx-2 reduction in either RBC, although a trend toward decreased Prx-2 oxidation over 5 min was noted in CO-treated cells ( p = 0.08 between with and without CO groups for b93Cys RBC). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(CHEBI:"hydrogen peroxide") positiveCorrelation p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(MGI:Prdx2) hasVariant p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(MGI:Prdx2, pmod(Ox)) positiveCorrelation a(CHEBI:"hydrogen peroxide") View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(MGI:Prdx2, pmod(Ox)) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(MGI:Prdx2, pmod(Ox)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Figure 5C shows that pretreatment of human RBC stored for 35 days with CO, or CO-added 5 min after H2O2, significantly accelerated Prx-2 reduction from the dimer to monomer (by *35% relative to control at 20 min). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.