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bp(GO:"endothelial cell activation")

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Entity

Name
endothelial cell activation
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 10

a(MESH:"Reactive Oxygen Species") increases bp(GO:"endothelial cell activation") View Subject | View Object

Heme activates neutrophils and endothelial cells, by ROS generation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:"nitric oxide") decreases bp(GO:"endothelial cell activation") View Subject | View Object

Because nitric oxide is known to prevent activation of endothelial cells and platelets, this nitric oxide deficiency promotes cellular activation. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:heme) increases bp(GO:"endothelial cell activation") View Subject | View Object

Heme activates endothelial cells inducing the expression of the adhesion molecules ICAM-1 (intercellular adhesion molecule 1), VCAM-1 (vascular cell adhesion molecule 1), E-selectin, Pselectin, and von Willebrand factor (VWF; Wagener et al., 1997; Belcher et al., 2014) and causes neutrophil migration (GraçaSouza et al., 2002; Porto et al., 2007). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"endothelial cell activation") View Subject | View Object

Heme is one of the factors capable of inducing stimulation and damage of endothelium, promoting the recruitment of neutrophils and sickle-cell erythro- cytes, and subsequently prompting a vaso-occlusive crisis. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) increases bp(GO:"endothelial cell activation") View Subject | View Object

Increased plasma concentrations of cell-free heme, the breakdown product of 390 hemoglobin, promote activation and inflammation of endothelial cells and enhance 391 oxidative stress and vascular permeability (22). PubMed:28314763

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

a(CHEBI:heme) increases bp(GO:"endothelial cell activation") View Subject | View Object

Free heme upregulates heme oxygenase activity, generates reactive oxygen species, and activates endothelial cells and macrophages directly[65]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:heme) positiveCorrelation bp(GO:"endothelial cell activation") View Subject | View Object

Free hemin is a cytotoxic molecule that mediates oxidative stress, endothelial activation, and inflammation, and it is implicated in malaria pathogenesis [40] and AKI, among others [41]. PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Serum
MeSH
Malaria
Text Location
Discussion

a(MESH:Cytokines) association bp(GO:"endothelial cell activation") View Subject | View Object

Finally, the cytokines produced through these pathways can then affect endothelial activation, leucocyte recruitment, and ultimately thrombotic risk. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:ferrylhemoglobin) increases bp(GO:"endothelial cell activation") View Subject | View Object

Similarly to heme, ferrylHb activates endothelial cells through NFκB activation (Silva et al., 2009). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

p(HGNC:HBB) increases bp(GO:"endothelial cell activation") View Subject | View Object

Extracellular hemoglobin sequesters NO and thus promotes activation of endothelial cells and adhesion/aggregation of platelets [64]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

Out-Edges 3

bp(GO:"endothelial cell activation") association a(MESH:Cytokines) View Subject | View Object

Finally, the cytokines produced through these pathways can then affect endothelial activation, leucocyte recruitment, and ultimately thrombotic risk. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(GO:"endothelial cell activation") decreases a(CHEBI:"nitric oxide") View Subject | View Object

In addition to cell-free Hb, membrane structural modification, externalization of phosphatidylserine,21 decreased cell membrane deformability,22,23 and increased endothelial adherence24 could alter vascular NO homeostasis. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Endothelium, Vascular
Text Location
Introduction

bp(GO:"endothelial cell activation") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Free hemin is a cytotoxic molecule that mediates oxidative stress, endothelial activation, and inflammation, and it is implicated in malaria pathogenesis [40] and AKI, among others [41]. PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Serum
MeSH
Malaria
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.