p(MGI:"signal transducer and activator of transcription 3")

Entity

Name

signal transducer and activator of transcription 3

Namespace

mgi

Namespace Version

20190224

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mgi-names.belns

Since p65 subunit of NF-κB and STAT3 were previously implicated in cytokine-induced expression of YKL-40 (8, 34), we knocked down their expression in human astrocytes PubMed:25681350

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

These data suggest that in addition to STAT3 activation, OSM enhances YKL-40 expression by promoting formation of the RelB/p50 complexes, which bind to the YKL-40 promoter PubMed:25681350

Since p65 subunit of NF-κB and STAT3 were previously implicated in cytokine-induced expression of YKL-40 (8, 34), we knocked down their expression in human astrocytes PubMed:25681350

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

Downregulation of STAT3 (Fig. 3C) dramatically diminished IL-1/OSM-induced YKL-40 mRNA expression (Fig. 3A). PubMed:25681350

Constitutively active STAT3 enhanced, whereas dominant-negative IκBα diminished cytokine-responsiveness. PubMed:25681350

Constitutively active STAT3 enhanced, whereas dominant-negative IκBα diminished cytokine-responsiveness. PubMed:25681350