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p(MGI:"interleukin 1 alpha")

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Entity

Name
interleukin 1 alpha
Namespace
mgi
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mgi-names.belns

Appears in Networks 1

RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

In-Edges 6

p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) View Subject | View Object

These experiments were performed in U373 glioma cells, which similarly to human and mouse astrocytes, upregulate expression of both YKL-40 and RelB in response to IL-1 and OSM, and this cytokine-induced expression is diminished by the knockdown of p50 and RelB (Suppl. Fig. 4). PubMed:25681350

Appears in Networks:

p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) View Subject | View Object

These experiments were performed in U373 glioma cells, which similarly to human and mouse astrocytes, upregulate expression of both YKL-40 and RelB in response to IL-1 and OSM, and this cytokine-induced expression is diminished by the knockdown of p50 and RelB (Suppl. Fig. 4). PubMed:25681350

Appears in Networks:

composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) hasComponent p(MGI:"interleukin 1 alpha") View Subject | View Object

Appears in Networks:

p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) View Subject | View Object

More importantly, OSM significantly enhanced IL-1-induced formation of the p50/RelB complexes PubMed:25681350

Appears in Networks:

p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) View Subject | View Object

Constitutively active STAT3 enhanced, whereas dominant-negative IκBα diminished cytokine-responsiveness. PubMed:25681350

Appears in Networks:

act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) View Subject | View Object

Constitutively active STAT3 enhanced, whereas dominant-negative IκBα diminished cytokine-responsiveness. PubMed:25681350

Appears in Networks:

Out-Edges 13

p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") View Subject | View Object

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases p(MGI:"signal transducer and activator of transcription 3") View Subject | View Object

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) View Subject | View Object

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") View Subject | View Object

Downregulation of STAT3 (Fig. 3C) dramatically diminished IL-1/OSM-induced YKL-40 mRNA expression (Fig. 3A). PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") View Subject | View Object

Similarly, RelB mRNA expression was also up-regulated by IL-1 in mouse astrocytes (Fig. 4D). PubMed:25681350

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte

p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) View Subject | View Object

These data suggests that RelB regulates expression of YKL-40 in response to proinflammatory cytokines, such as IL-1 and TNF, which induce canonical activation of RelB/p50 complexes. PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) View Subject | View Object

These data suggests that RelB regulates expression of YKL-40 in response to proinflammatory cytokines, such as IL-1 and TNF, which induce canonical activation of RelB/p50 complexes. PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) View Subject | View Object

Indeed, p50/RelB complexes were formed in response to IL-1 PubMed:25681350

Appears in Networks:

act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) View Subject | View Object

More importantly, OSM significantly enhanced IL-1-induced formation of the p50/RelB complexes PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) View Subject | View Object

These experiments were performed in U373 glioma cells, which similarly to human and mouse astrocytes, upregulate expression of both YKL-40 and RelB in response to IL-1 and OSM, and this cytokine-induced expression is diminished by the knockdown of p50 and RelB (Suppl. Fig. 4). PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) View Subject | View Object

In agreement with the mutational analysis that showed the importance of the proximal NF-κB site (Fig. 3D), strong protein binding to the proximal, but not distal, NF-κB site of the YKL-40 promoter was induced by IL-1 alone or together with OSM (Fig. 5C). PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") regulates p(MGI:"chitinase-like 1") View Subject | View Object

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") View Subject | View Object

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B). PubMed:25681350

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.