ELANE

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: ELANE
Namespace: hgnc
Namespace Version: 20180906
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

p(HGNC:SERPINA1) decreases p(HGNC:ELANE) View Subject | View Object

The main function of A1AT is to inhibit neutrophil elastase and proteinase 3. PubMed:28716864

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): neutrophil
MeSH: Serum
MeSH: Malaria
Text Location: Discussion

Out-Edges 1

p(HGNC:ELANE) increases deg(p(HGNC:HBB)) View Subject | View Object

For instance, earlier studies have demonstrated that neutrophil elastase degrades the hemoglobin liberating free hemin that induces ROS production. PubMed:28716864

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): neutrophil
MeSH: Serum
MeSH: Malaria
Text Location: Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.