1. Catalog
  2. Nodes
  3. p(HGNC:EIF2S1, pmod(Ph))

p(HGNC:EIF2S1, pmod(Ph))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
EIF2S1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

The Biology of Proteostasis in Aging and Disease v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Activation and regulation of the inflammasomes v1.0.0

In-Edges 3

act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) View Subject | View Object

Finally, a third ER transmembrane protein, PERK, promotes translation of the TF ATF4 by phosphorylating the translation initiation factor eIF2α in response to ER stress. PubMed:25784053

Appears in Networks:

p(HGNC:EIF2S1) hasVariant p(HGNC:EIF2S1, pmod(Ph)) View Subject | View Object

Appears in Networks:

act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) View Subject | View Object

The growth arrest and DNA damage protein (GADD) 34 is up-regulated in response to ER stress and regulates subunit of protein phosphatase 1 (PP1) complex that dephosphorylates eukaryotic translation initiator factor 2α (elF2α). PubMed:26142647

Appears in Networks:

Out-Edges 2

p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) View Subject | View Object

Finally, a third ER transmembrane protein, PERK, promotes translation of the TF ATF4 by phosphorylating the translation initiation factor eIF2α in response to ER stress. PubMed:25784053

Appears in Networks:

p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) View Subject | View Object

Protein synthesis could be inhibited by the phosphorylation of the initiation factor eukaryotic translation initiation factor 2 subunit-α (EIF2α; also known as EIF2S1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.