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p(HGNC:NFKBIA, pmod(Ph))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NFKBIA
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc-names.belns

Appears in Networks 2

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 9

a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Besides, it decreased the phosphorylation of IKK and IB through LPS stimulation and subse-quently inhibited the activity of NF-B [115]. PubMed:29179999

Appears in Networks:

a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Macranthoin G inhibited the NF-B pathway and activated the phosphorylation of IB, p38 and ERK, and thus, min-imized cell damage [131]. PubMed:29179999

Appears in Networks:

a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Also, berberine inhibited the phosphorylation of IB. PubMed:29179999

Appears in Networks:

a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Inhibition of the NF-B pathway represents a well-defined anti-inflammatory mechanism of curcumin[104,105]. Curcumin inhibited the phosphorylation and degrada-tion of IB and the nuclear translocation of NF-B p65 [106]. PubMed:29179999

Appears in Networks:

p(HGNC:NFKBIA) hasVariant p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Appears in Networks:

a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

ROS generation leads to phosphorylation of NF-κB cytoplasmic inhibitor IκBα. NF-κB is thus liberated and transports to the nucleus. PubMed:27288790

Appears in Networks:

a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Omega-6 phospholipids, e.g. dilinoleoylphosphatidylcholine (DLPC), have been shown to block TNF-α and H 2 O 2 activation of MAPK as well as blocks IκBα phosphorylation in the SH-SY5Y cells and prevents the phosphorylation and activation of NF-κB. PubMed:27288790

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y
MeSH
Cerebral Cortex
MeSH
Hippocampus

act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

Treatment with p38 inhibitor, SB239063, prevents downstream phosphorylation of IκBα and p65 translocation to the nucleus in the ventral midbrain. PubMed:27288790

Appears in Networks:

act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) View Subject | View Object

In contrast, SP600125 treatment, a JNK inhibitor, increases the p38 MAPK depen- dent phosphorylation of p65 NF-κB subunit in the nucleus [47]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Cell Nucleus

Out-Edges 1

p(HGNC:NFKBIA, pmod(Ph)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) View Subject | View Object

ROS generation leads to phosphorylation of NF-κB cytoplasmic inhibitor IκBα. NF-κB is thus liberated and transports to the nucleus. PubMed:27288790

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.