D016874

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: D016874
Namespace: MeSH
Namespace Version: 20181007
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh.belns

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 3

a(MESH:D059329) association a(MESH:D016874) View Subject | View Object

Cholinergic basal forebrain (CBF) cortical projection neurons contain the pathological AD hallmark, neurofibrillary tangles (NFTs), and undergo chemical phenotypic alterations during the progression of AD, making them an excellent natural model for studying mechanisms of cell death, survival and treatment approaches both in vitro and in vivo, including relevant animal models of neurodegeneration as well as human postmortem clinical pathological tissue studies [14]. PubMed:18986241

Appears in Networks:

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Annotations

Disease Ontology (DO): Alzheimer's disease
MeSH: Basal Forebrain

p(HGNC:BCHE) association a(MESH:D016874) View Subject | View Object

Butyrylcholinesterase (BChE) is a serine hydrolase similar to AChE that is widely distributed throughout the CNS and also catalyzes the hydrolysis of ACh. BChE is localized to neurons and glia, and is associated with NFTs and senile plaques (SPs) in AD brain [32]. Interestingly, population-based genetic studies of AD have identified a point mutation that changes Ala539 to threonine in the K variant of BChE, which effectively reduces serum BChE concentrations, and may be associated with cognitive decline [33]. BChE activity also increases in AD brain whereas AChE activity remains unchanged or declines [34,35]. PubMed:18986241