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a(CHEBI:thapsigargin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
thapsigargin
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

In-Edges 4

a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) View Subject | View Object

Nicotine protects SH-SY5Y cells from cell death induced by thapsigargin, an inhibitor of the sarcoplasmic-reticulum calcium pump (Arias et al., 2004). PubMed:19293145

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) hasComponent a(CHEBI:thapsigargin) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) hasComponent a(CHEBI:thapsigargin) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) hasComponent a(CHEBI:thapsigargin) View Subject | View Object

Appears in Networks:

Out-Edges 3

a(CHEBI:thapsigargin) increases bp(GO:"cell death") View Subject | View Object

Nicotine protects SH-SY5Y cells from cell death induced by thapsigargin, an inhibitor of the sarcoplasmic-reticulum calcium pump (Arias et al., 2004). PubMed:19293145

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") View Subject | View Object

Nicotine protects SH-SY5Y cells from cell death induced by thapsigargin, an inhibitor of the sarcoplasmic-reticulum calcium pump (Arias et al., 2004). PubMed:19293145

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") View Subject | View Object

Cells expressing WT tau behave as control cells and display a dose-dependent increase in CMA activity upon exposure to paraquat (Fig. 3f) or thapsigargin (Fig. 3g) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Intracellular Space
Confidence
High
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.