composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT))

Components

• a(HBP:"Tau aggregates")
• p(HGNC:MAPT)

Compared to monomers, aggregation significantly increased PAD exposure for both hT40 and S422E samples (Fig. 3B; F(1,12) = 685.8, p b 0.0001), as indicated by increased TNT1 reactivity. Aggregation also significantly increased oligomer formation (TOC1 reactivity) compared to monomers in both hT40 and S422E samples (Fig. 3C; F(1,12) = 109.3, p b 0.0001). PubMed:27373205

In contrast, aggregation of either hT40 or S422E significantly increased the amount of SDS-stable dimers at 180 kDa (Fig. 4C; F(1,12) = 110.0; p b 0.0001), as compared to the levels of these species in the respective monomer samples. Furthermore, S422E aggregation significantly increased the amount of SDS-stable dimers compared to hT40 aggregation (p = 0.03). PubMed:27373205

As previously reported, perfusion of hT40 monomer had no effect on the rate of anterograde FAT in the squid axoplasm (Fig. 5A), whereas perfusion of hT40 aggregates significantly inhibited anterograde FAT as compared to hT40 monomer (Fig. 5B; Fig. 6A; p = 0.003) (LaPointe et al., 2009b). Neither hT40 monomers nor hT40 aggregates altered the rate of retrograde FAT (Fig. 5A, B; Fig. 6B). PubMed:27373205

As previously reported, perfusion of hT40 monomer had no effect on the rate of anterograde FAT in the squid axoplasm (Fig. 5A), whereas perfusion of hT40 aggregates significantly inhibited anterograde FAT as compared to hT40 monomer (Fig. 5B; Fig. 6A; p = 0.003) (LaPointe et al., 2009b). Neither hT40 monomers nor hT40 aggregates altered the rate of retrograde FAT (Fig. 5A, B; Fig. 6B). PubMed:27373205