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p(HGNC:DPYSL2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
DPYSL2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 7

bp(GO:"axon development") association p(HGNC:DPYSL2) View Subject | View Object

This gene is located on chromosome 8p21 and it encodes the cytosolic microtubule-associated protein CRMP2 (collapsin response mediator protein-2), which is highly expressed in the CNS and plays a role in axonal growth PubMed:30061532

Appears in Networks:

complex(a(GO:"actin cytoskeleton"), p(HGNC:DPYSL2)) hasComponent p(HGNC:DPYSL2) View Subject | View Object

Appears in Networks:

complex(a(GO:microtubule), p(HGNC:DPYSL2)) hasComponent p(HGNC:DPYSL2) View Subject | View Object

Appears in Networks:

p(HGNC:CDK5) regulates p(HGNC:DPYSL2) View Subject | View Object

In line with this, the dendritic spine-regulating activity of CRMP2 is under the control of the cyclin-dependent kinase 5 (CDK5) PubMed:30061532

Appears in Networks:

complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) hasComponent p(HGNC:DPYSL2) View Subject | View Object

Appears in Networks:

g(HGNC:DPYSL2) increases p(HGNC:DPYSL2) View Subject | View Object

This gene is located on chromosome 8p21 and it encodes the cytosolic microtubule-associated protein CRMP2 (collapsin response mediator protein-2), which is highly expressed in the CNS and plays a role in axonal growth PubMed:30061532

Appears in Networks:

path(MESH:Schizophrenia) association p(HGNC:DPYSL2) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

Out-Edges 4

p(HGNC:DPYSL2) hasVariant p(HGNC:DPYSL2, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:DPYSL2) association path(MESH:Schizophrenia) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

p(HGNC:DPYSL2) association bp(GO:"axon development") View Subject | View Object

This gene is located on chromosome 8p21 and it encodes the cytosolic microtubule-associated protein CRMP2 (collapsin response mediator protein-2), which is highly expressed in the CNS and plays a role in axonal growth PubMed:30061532

Appears in Networks:

p(HGNC:DPYSL2) regulates a(GO:"dendritic spine") View Subject | View Object

In line with this, the dendritic spine-regulating activity of CRMP2 is under the control of the cyclin-dependent kinase 5 (CDK5) PubMed:30061532

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.