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PubMed: 24486321

Title
Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.
Journal
Free radical biology & medicine
Volume
69
Issue
None
Pages
265-77
Date
2014-04-01
Authors
Alayash AI | Banerjee S | Crumbliss AL | Jia Y | Kreulen RT | Mollan TL | Olson JS | Tsai AL | Wu G

Evidence 5fa4b2d3cb
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Ferryl heme and associated protein radicals with high redox potentials (~1.0 V) can induce a wide variety of oxidative reactions that affect the protein and nearby molecules [2].

a(CHEBI:heme) positiveCorrelation a(HM:"oxidative reactions") View Subject | View Object

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a(HM:"oxidative reactions") positiveCorrelation a(CHEBI:heme) View Subject | View Object

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Evidence 73f5a7b976
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First, addition of exogenous Hp both markedly inhibits heme loss and second, as a result of this inhibition, globin precipitation is prevented.

a(CHEBI:heme) positiveCorrelation p(HGNC:HP) View Subject | View Object

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p(HGNC:HP) positiveCorrelation a(CHEBI:heme) View Subject | View Object

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Evidence f2eaf92a88
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Hp bound metHb and prevented heme loss and hemopexin captures any free heme released from metHb during its denaturation.

deg(a(CHEBI:methemoglobin)) increases a(CHEBI:heme) View Subject | View Object

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MeSH
Anemia, Sickle Cell
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p(MGI:Hpx) decreases a(CHEBI:heme) View Subject | View Object

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Anemia, Sickle Cell
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Evidence 12e9b74e87
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For example, autooxidation of oxyhemoglobin (HbO2) or oxymyoglobin (MbO2) produces met-Hb or met-Mb, respectively, and superoxide radicals (O2•−, HO2•) via electron transfer [3,4].

a(CHEBI:oxyhemoglobin) increases a(CHEBI:methemoglobin) View Subject | View Object

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Evidence 43fee2f70e
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This result is in accord with recent work, which showed that Hp binding to Hb prevents oxidative damage to the globin.

a(MESH:"haptoglobin-hemoglobin complex") decreases a(HM:"oxidative reactions") View Subject | View Object

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Anemia, Sickle Cell
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Evidence 002f6c9ba1
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For example, Hp 2-2 has been associated with an increased susceptibility to diabetic cardiovascular disease; uptake of Hb-Hp(1-1) complexes by CD163 receptors is reportedly faster and its binding results in increased concentrations of anti-inflammatory mediators than Hb-Hp(2-2) complexes; and the angiogenic potency of Hp 2-2 is reportedly greater than that of Hp 1-1 [18].

a(MESH:"haptoglobin-hemoglobin complex") decreases path(MESH:Inflammation) View Subject | View Object

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Evidence bc1284c200
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Hemolysis and the transfusion of banked blood or Hb-based therapeutics can result in varying quantities of circulating acellular Hb which can induce life threatening radical generating reactions in patients with a compromised vascular system [60].

p(HGNC:HBB) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

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p(HGNC:HBB) positiveCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

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path(MESH:"Vascular System Injuries") positiveCorrelation p(HGNC:HBB) View Subject | View Object

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path(MESH:Hemolysis) positiveCorrelation p(HGNC:HBB) View Subject | View Object

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Evidence 29f3398bc1
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Third, exposure to extracellular Hb, in the form of oxygen therapeutics or when Hb is released from old red blood cells, have also been reported to induce oxidative toxicity in kidney and brain tissues [65].

p(HGNC:HBB) positiveCorrelation path(MESH:"Kidney Diseases") View Subject | View Object

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p(HGNC:HBB) positiveCorrelation path(MESH:"Brain Diseases") View Subject | View Object

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path(MESH:"Brain Diseases") positiveCorrelation p(HGNC:HBB) View Subject | View Object

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path(MESH:"Kidney Diseases") positiveCorrelation p(HGNC:HBB) View Subject | View Object

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Evidence 5100deb4fe
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In that study, heme was shown to specifically bind to endothelial Toll-like receptors (TLR4) and trigger a cascade of inflammatory responses, which could be attributed to oxidation and degradation of cell-free Hb [73].

deg(p(HGNC:HBB)) increases a(CHEBI:heme) View Subject | View Object

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MeSH
Anemia, Sickle Cell
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complex(a(CHEBI:heme), p(MGI:Tlr4)) positiveCorrelation path(MESH:Inflammation) View Subject | View Object

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Anemia, Sickle Cell
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path(MESH:Inflammation) positiveCorrelation complex(a(CHEBI:heme), p(MGI:Tlr4)) View Subject | View Object

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Anemia, Sickle Cell
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Evidence 26d7b72006
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These findings are consistent with a recent study which showed that both Hp and hemopexin (heme scavenger) were equally effective in preventing vasoocclusion in a sickle cell mouse model infused with Hb [73].

p(MGI:Hpx) decreases path(HM:"vaso-occlusive crisis") View Subject | View Object

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Anemia, Sickle Cell
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p(MGI:Hp) decreases path(HM:"vaso-occlusive crisis") View Subject | View Object

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Anemia, Sickle Cell
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Evidence 709f133546
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Haptoglobin (Hp) is an abundant and conserved plasma glycoprotein, which binds acellular adult hemoglobin (Hb) dimers with high affinity and facilitates their rapid clearance from circulation following hemolysis.

p(HGNC:HP) decreases p(HGNC:HBB) View Subject | View Object

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Abstract

Evidence a50d4a5763
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Haptoglobin (Hp) is a Hb-scavenging plasma glycoprotein which binds non-covalently to hemoglobin dimers that are generated by dissociation of acellular Hb tetramers after hemolysis [6].

p(HGNC:HP) decreases p(HGNC:HBB) View Subject | View Object

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Evidence 577bbfd6e3
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Hp is the first-line scavenger that binds and accelerates the clearance of Hb in the circulation, although the macrophage CD163 receptor has also been the focus of several recent investigations [66– 68].

p(HGNC:HP) decreases p(HGNC:HBB) View Subject | View Object

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Evidence 4fe46f95e7
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Probably the most important Hp-mediated abrogation of Hb toxicity is stabilization of heme within the central cavity of the Hb subunits, which almost completely prevents its dissociation and subsequent free heme-mediated oxidative reactions and inflammatory responses.

p(HGNC:HP) decreases a(HM:"oxidative reactions") View Subject | View Object

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p(HGNC:HP) decreases path(MESH:Inflammation) View Subject | View Object

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