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PubMed: 24489717

Title
A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia.
Journal
PloS one
Volume
9
Issue
None
Pages
e86353
Date
2014-01-01
Authors
Gram M | Edström-Hägerwall A | Hansson SR | Johansson ME | Larsson I | Wester-Rosenlöf L | Akerström B | Axelsson J | Casslén V | Holmqvist M | Ley D | Marsal K | Mörgelin M | Rippe B | Rutardottir S | Shohani B

Evidence e96c16f502
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The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23].

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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p(HGNC:HBB) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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p(HGNC:AMBP) positiveCorrelation p(HGNC:HBB) View Subject | View Object

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p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme) View Subject | View Object

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p(HGNC:AMBP) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

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Introduction

Evidence 0fefacb13c
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However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection.

a(MESH:Lymphocytes) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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Results

a(MESH:Monocytes) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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bp(MESH:"Leukocyte Count") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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Results

bp(MESH:"Platelet Count") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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Results

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Platelet Count") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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Results

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Leukocyte Count") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
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Results

p(HGNC:AMBP) positiveCorrelation a(MESH:Lymphocytes) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

Evidence 07ce4c3c48
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However, A1M treatment led to a significant reduction in systolic, diastolic and mean arterial blood pressure 24 hours after the first injection (Figure 2, and Figure S1), but no change in heart rate (Figure S1).

bp(HP:"regulation of systemic arterial blood pressure") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

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p(HGNC:AMBP) positiveCorrelation bp(HP:"regulation of systemic arterial blood pressure") View Subject | View Object

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Evidence 958a56ccda
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The placenta histology revealed an increased erythrophagocytosis in the starved placebo treated animals compared to controls. A1M-treatment appeared to attenuate phagocytosis (Figure 5).

p(HGNC:AMBP) decreases bp(MESH:Phagocytosis) View Subject | View Object

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erythrocyte
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Evidence e50c231ed7
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Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels).

p(HGNC:AMBP) negativeCorrelation path(MESH:Necrosis) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
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Results

path(MESH:Necrosis) negativeCorrelation p(HGNC:AMBP) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
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Evidence a652b064cb
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Plasma creatinine concentration increased significantly in the placebo treated animals at 4 hours of follow-up, but not in the A1M treated group (Figure 9B).

p(HGNC:AMBP) causesNoChange a(CHEBI:creatinine) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

Evidence 02f5e08e5d
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Treatment with A1M led to a small, non-significant, transient increase in plasma interleukin 6 24 hours after the first injection.

p(HGNC:AMBP) increases p(HGNC:IL6) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

Evidence a428965ee1
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Starvation led to a significantly down-regulation of the oxidative stress-related SOD1 (p,0.008) and catalase (p,0.043) in blood, but a 2.6-fold up-regulation of catalase in placenta (Figure 10A).

p(HGNC:AMBP) decreases p(HGNC:SOD1) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Results

p(HGNC:AMBP) decreases a(CHEBI:Catalase) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Blood
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Results

p(HGNC:AMBP) increases a(CHEBI:Catalase) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Placenta
Text Location
Results

Evidence a8123ad40b
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Treatment of starved ewes with A1M up-regulated the expression of SOD2 (p,0.043) and down-regulated the expression of s-Flt1 (p,0.012), in blood (Figure 11).

p(HGNC:AMBP) increases p(HGNC:SOD2) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Blood
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p(HGNC:AMBP) decreases p(HGNC:FLT1) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Blood
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