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PubMed: 29807032

Title
Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis.
Journal
General and comparative endocrinology
Volume
265
Issue
None
Pages
207-213
Date
2018-09-01
Authors
Alderman SL | Bernier NJ | Fuzzen MLM | Leishman EM

Evidence 5aa46d4cdd
JSON

However, embryos that recovered from heat shock in the presence of the CRF-R1 antagonist, antalarmin, experienced a greater increase in caspase-3 activity than embryos not given the antagonist

a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence 7c9625cee3
JSON

The greatest heat shock-induced mortality occurred during the first 1 h of recovery and plateaued after 5 h recovery (main effect of time P<0.001; n=3; Fig. 3B), but the presence of antalarmin did not influence this response.

a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence 728617e675
JSON

The endogenous response to heat shock was characterized by transient changes in caspase-3 activity and gene expression.

bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) View Subject | View Object

Appears in Networks:

act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") View Subject | View Object

Appears in Networks:

Evidence d19607d225
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For embryos heat shocked at 6 hpf, the induction of caspase-3 activity was dependent on recovery time (interaction of main variables P=0.007), with a significant increase over controls at 7 h and 10 h recovery (Table 1).

bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) View Subject | View Object

Appears in Networks:

Evidence 60009a9415
JSON

In embryos heat shocked at 6 hpf, crf abundance increased relative to controls after 4 h recovery, but there were no differences at 7 h or 10 h recovery (Fig. 1A).

bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence bab24cead8
JSON

The endogenous response to heat shock was also characterized by an increase in crf-bp mRNA levels independent of recovery time (main effect of heat shock P<0.05), and this was true for embryos exposed to the stressor at 6 hpf (Fig. 1C) and at 30 hpf (Fig. 1D).

bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence 24efeb0e2b
JSON

Heat shock significantly increased embryo mortality relative to non-heat shocked embryos

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence 5cc2b466a7
JSON

Final cumulative mortality (at 10 h recovery) in non-heat shocked embryos was low in both the 0 nM and 10 nM antalarmin groups (4.7% and 8.3%, respectively), and heat shock increased mortality in both groups

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

Evidence 944ca972c0
JSON

CRF overexpression by mRNA microinjection reduced heat shock-induced caspase-3 activity by approximately 2-fold relative to control-injected embryos

p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

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