p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia")

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PubMed:24368848

We found that in the visual cortex, neurons containing conspicuous quantities of mislocalized and aggregated tau nonetheless appear to have a normal capacity to integrate dendritic inputs and respond robustly to visual stimuli and also maintain normal somatic baseline calcium levels. In particular, we show that individual NFT-bearing neurons can respond robustly after integrating sensory inputs and are functionally indistinguishable from neighboring non–NFT-bearing neurons. These results demonstrate that NFT-bearing neurons remain functionally integrated in cortical circuits.

Related Edges 1

• complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons))

MeSH

Frontotemporal Dementia

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