Title

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

111

Issue

None

Pages

510-4

Date

2014-01-07

Authors

Andermann ML | Bacskai BJ | Hawkes J | Hyman BT | Kopeikina KJ | Kuchibhotla KV | Rudinskiy N | Spires-Jones TL | Wegmann S

We found that in the visual cortex, neurons containing conspicuous quantities of mislocalized and aggregated tau nonetheless appear to have a normal capacity to integrate dendritic inputs and respond robustly to visual stimuli and also maintain normal somatic baseline calcium levels. In particular, we show that individual NFT-bearing neurons can respond robustly after integrating sensory inputs and are functionally indistinguishable from neighboring non–NFT-bearing neurons. These results demonstrate that NFT-bearing neurons remain functionally integrated in cortical circuits.

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