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p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu"))

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Entity

Name
Tau isoform F (441 aa)
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 1

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

In-Edges 1

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") View Subject | View Object

We found that in the visual cortex, neurons containing conspicuous quantities of mislocalized and aggregated tau nonetheless appear to have a normal capacity to integrate dendritic inputs and respond robustly to visual stimuli and also maintain normal somatic baseline calcium levels. In particular, we show that individual NFT-bearing neurons can respond robustly after integrating sensory inputs and are functionally indistinguishable from neighboring non–NFT-bearing neurons. These results demonstrate that NFT-bearing neurons remain functionally integrated in cortical circuits. PubMed:24368848

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Annotations
MeSH
Frontotemporal Dementia

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.