a(CHEBI:fisetin) increases act(p(FPLX:mTORC1))

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PubMed:30116051

Moreover, the flavonol fisetin stimulated auto- phagic degradation of phosphorylated tau in cortical neu- rons via mTORC1-dependent activation of TFEB and the cytoprotective transcription factor nuclear factor eryth- roid 2-related factor 2 (NFE2L2) 149 . Fisetin also reduced Aβ accumulation in an APP/PS1 mouse model of AD 150 .

Related Edges 5

• a(CHEBI:fisetin) increases bp(GO:macroautophagy)
• a(CHEBI:fisetin) decreases a(HBP:HBP00018)
• bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007)))
• act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB))
• act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2))

MeSH

Dopaminergic Neurons

MeSH

Machado-Joseph Disease

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