a(CHEBI:fisetin) increases bp(GO:macroautophagy)

View Subject View Object

PubMed:30116051

Moreover, the flavonol fisetin stimulated auto- phagic degradation of phosphorylated tau in cortical neu- rons via mTORC1-dependent activation of TFEB and the cytoprotective transcription factor nuclear factor eryth- roid 2-related factor 2 (NFE2L2) 149 . Fisetin also reduced Aβ accumulation in an APP/PS1 mouse model of AD 150 .

Related Edges 5

• a(CHEBI:fisetin) increases act(p(FPLX:mTORC1))
• a(CHEBI:fisetin) decreases a(HBP:HBP00018)
• bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007)))
• act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB))
• act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2))

MeSH

Dopaminergic Neurons

MeSH

Machado-Joseph Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---