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a(HBP:"alpha-Bungarotoxin")

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Entity

Name
alpha-Bungarotoxin
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp-names.belns

Appears in Networks 4

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Identification and Characterization of a G Protein-binding Cluster in alpha7 Nicotinic Acetylcholine Receptors v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

In-Edges 4

complex(a(HBP:"alpha-7-containing nAChR"), a(HBP:"alpha-Bungarotoxin")) hasComponent a(HBP:"alpha-Bungarotoxin") View Subject | View Object

Appears in Networks:

complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) hasComponent a(HBP:"alpha-Bungarotoxin") View Subject | View Object

Appears in Networks:

complex(a(HBP:"alpha-Bungarotoxin"), p(FPLX:CHRN)) hasComponent a(HBP:"alpha-Bungarotoxin") View Subject | View Object

Appears in Networks:

complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) hasComponent a(HBP:"alpha-Bungarotoxin") View Subject | View Object

Appears in Networks:

Out-Edges 4

a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) View Subject | View Object

The second was the discovery of alpha-bungarotoxin (alpha-BGT), a component of krait snake venom that binds muscle-type nAChRs with near covalent affinity to inhibit their function and promote debilitating paralysis at the neuromuscular junction (6, 50, 149, 264). PubMed:19126755

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Text Location
Review

a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) View Subject | View Object

The most valuable of these toxins to researchers proved to be alpha-BGT from the snake Bungarus multicinctus. Because this toxin binds to the muscle nAChR with great specificity and a near-covalent affinity, it was an invaluable tool in the purification of the first nAChRs (discussed above). PubMed:19126755

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Text Location
Review

a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) View Subject | View Object

Activation of alpha7 nAChRs is known to contribute to the regulation of extracellular dopamine levels in the rat striatum (81). Application via microdialysis of KYNA or alpha-BGT to the rat striatum significantly reduces the extracellular levels of dopamine, and the magnitude of the effect of either antagonist alone is comparable to that of both antagonists together (285). PubMed:19126755

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Annotations
MeSH
Corpus Striatum
Text Location
Review

a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

First, postmortem studies of the hippocampus and thalamus show diminished labeling of putative inhibitory neurons by alpha-bungarotoxin, an antagonist of alpha7 nAChRs (Court et al., 1999) PubMed:21482353

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Annotations
MeSH
Schizophrenia

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.