1. Catalog
  2. Nodes
  3. path(HP:"Hemolytic anemia")

path(HP:"Hemolytic anemia")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Hemolytic anemia
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

bp(MESH:Erythropoiesis) positiveCorrelation path(HP:"Hemolytic anemia") View Subject | View Object

Therefore, hemolytic anemia in CEP mice activates a compensatory stress erythropoiesis with no sign of ineffective erythropoiesis. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(HP:"Paroxysmal nocturnal hemoglobinuria") association path(HP:"Hemolytic anemia") View Subject | View Object

Inhibition of the terminal complement cascade by eculizumab (inhibits the cleavage of C5 into C5a und C5b and thus the formation of the membrane attack complex 8, MAC C5b-C9) for the treatment of hemolytic paroxymal nocturnal hemoglobinuria (PNH) significantly prevented PNH-related symptoms in patients including abnormal thrombophilia, red blood cell destruction, and the extent of hemolysis [76]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

Out-Edges 2

path(HP:"Hemolytic anemia") positiveCorrelation bp(MESH:Erythropoiesis) View Subject | View Object

Therefore, hemolytic anemia in CEP mice activates a compensatory stress erythropoiesis with no sign of ineffective erythropoiesis. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(HP:"Hemolytic anemia") association path(HP:"Paroxysmal nocturnal hemoglobinuria") View Subject | View Object

Inhibition of the terminal complement cascade by eculizumab (inhibits the cleavage of C5 into C5a und C5b and thus the formation of the membrane attack complex 8, MAC C5b-C9) for the treatment of hemolytic paroxymal nocturnal hemoglobinuria (PNH) significantly prevented PNH-related symptoms in patients including abnormal thrombophilia, red blood cell destruction, and the extent of hemolysis [76]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.