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Appears in Networks 4

In-Edges 3

p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

All the mammalian neuronal nAChR subtypes do share the general func- tional property of being permeable to small monovalent and divalent cations. The main conducting species under biological conditions are Na+, K+, and Ca2+. PubMed:26472524

p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

All the mammalian neuronal nAChR subtypes do share the general func- tional property of being permeable to small monovalent and divalent cations. The main conducting species under biological conditions are Na+, K+, and Ca2+. PubMed:26472524

Out-Edges 6

a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

Annotations
Confidence
High
NeuroMMSigDB
XIAP subgraph

a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) View Subject | View Object

In addition, high extracellular levels of K+ can block IL-1β release after NLRC4 and AIM2 inflammasome formation80,81, which indicates that low intracellular K+ levels might also be required for the activation of these inflammasomes. PubMed:23702978

a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.