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bp(GO:"apoptosome assembly")

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Entity

Name
apoptosome assembly
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Activation and regulation of the inflammasomes v1.0.0

In-Edges 3

a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
XIAP subgraph

a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") View Subject | View Object

In particular, ROS facilitate the assembly of the apoptosome in several ways. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Apoptosis signaling subgraph

complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
XIAP subgraph

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.