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complex(p(HGNC:APAF1), p(HGNC:CYCS))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 2

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Activation and regulation of the inflammasomes v1.0.0

In-Edges 1

tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
XIAP subgraph

Out-Edges 4

complex(p(HGNC:APAF1), p(HGNC:CYCS)) hasComponent p(HGNC:APAF1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APAF1), p(HGNC:CYCS)) hasComponent p(HGNC:CYCS) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) View Subject | View Object

Suggestively, as tau oligomers concentrate at the mitochondrial membrane, cytochrome C is released, leading to caspase-9 activation via a complex with apoptotic-peptidase activating- factor-1 (Apaf-1; Li et al., 1997) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Mitochondrial Membranes
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
XIAP subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.