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p(HGNC:CASP9)

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Entity

Name
CASP9
Namespace
HGNC
Namespace Version
20180215
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hgnc/hgnc-20180215.belns

Appears in Networks 2

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Activation and regulation of the inflammasomes v1.0.0

In-Edges 6

a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) View Subject | View Object

Hemispheres injected with tau oligomers were found to have increased levels of caspase-9 activation (Lasagna-Reeves et al., 2011) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) View Subject | View Object

Suggestively, as tau oligomers concentrate at the mitochondrial membrane, cytochrome C is released, leading to caspase-9 activation via a complex with apoptotic-peptidase activating- factor-1 (Apaf-1; Li et al., 1997) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Mitochondrial Membranes
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

complex(p(HGNC:CARD8), p(HGNC:CASP9)) hasComponent p(HGNC:CASP9) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) View Subject | View Object

CARD8 has multiple functions in regulating apoptosis, one of which is to directly bind to procaspase 9 and to suppress its activation109. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Caspase subgraph

p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) View Subject | View Object

By contrast, nitrosylation of caspase 9 inhibits its function94. Similarly, caspase 1 can be inhibited by nitrosylation95, which suggests that modification by reactive molecules is a general mechanism for the regulation of caspase activity. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Caspase subgraph

Out-Edges 1

p(HGNC:CASP9) hasVariant p(HGNC:CASP9, pmod(NO)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.