1. Catalog
  2. Nodes
  3. a(GO:presynapse)

a(GO:presynapse)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
presynapse
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 8

a(CHEBI:adenosine) decreases act(a(GO:presynapse)) View Subject | View Object

Adenosine downmodulates neuronal activity (cFos levels), impairs the presynapse, and attenuates long-term potentiation (LTP) via the A1 receptor (21) PubMed:27671637

Appears in Networks:

a(MESH:"BSc 3094") increases act(a(GO:presynapse)) View Subject | View Object

In line with these observations, the presynaptic impairment in proaggregant Tau transgenic slices can be reversed by 64627 or BSc3094 without causing adverse effects in controls (Fig. 4F and Fig. S6) PubMed:27671637

Appears in Networks:

a(PUBCHEM:64627) increases act(a(GO:presynapse)) View Subject | View Object

In line with these observations, the presynaptic impairment in proaggregant Tau transgenic slices can be reversed by 64627 or BSc3094 without causing adverse effects in controls (Fig. 4F and Fig. S6) PubMed:27671637

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) View Subject | View Object

We observed a typical paired-pulse facilitation (PPF) response in littermate controls and antiaggregant Tau transgenic slices, whereas in proaggregant Tau transgenic slices, the same stimulus paradigm resulted in a paired-pulse depression (Fig. 4B) PubMed:27671637

Appears in Networks:

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) View Subject | View Object

Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well PubMed:27671637

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) View Subject | View Object

We observed a typical paired-pulse facilitation (PPF) response in littermate controls and antiaggregant Tau transgenic slices, whereas in proaggregant Tau transgenic slices, the same stimulus paradigm resulted in a paired-pulse depression (Fig. 4B) PubMed:27671637

Appears in Networks:

act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) View Subject | View Object

Adenosine downmodulates neuronal activity (cFos levels), impairs the presynapse, and attenuates long-term potentiation (LTP) via the A1 receptor (21) PubMed:27671637

Appears in Networks:

a(HBP:"Tau aggregates") decreases a(GO:presynapse) View Subject | View Object

One exception is the report of the accumulation of tau aggregates in presynaptic boutons in transgenic mice, whereby it induces synaptic dysfunction and loss of presynapses (77). PubMed:29191965

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.