composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")))
Indeed, the reduced level of spines seen in proaggregant Tau transgenic slices are normalized when treated with 64627, whereas no significant changes are found in antiaggregant Tau transgenic slices or littermate controls (Fig. 5 A and B) PubMed:27671637
Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well PubMed:27671637
Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well PubMed:27671637
Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well PubMed:27671637
Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well PubMed:27671637
64627 reestablished novel arm preference in proaggregant mice, suggesting that 64627 restores spatial memory in these animals PubMed:27671637
64627 treatment improved long-term object recognition memory in proaggregant Tau transgenic mice, as shown by increased novel object preference PubMed:27671637
This result suggests an impaired learning association between the sound and the foot shock in proaggregant mice, which can be rescued by 64627 treatment PubMed:27671637
Compared with untreated proaggregant Tau transgenic mice, treated mice (proaggregant Tau transgenics and littermate controls) have significantly larger maximal excitatory postsynaptic potential amplitudes (Fig. 5 G–I) PubMed:27671637
Treatment with 64627 increases the slope of the I/O curve in both proaggregant Tau transgenic slices and littermate controls (Fig. 5I). PubMed:27671637
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.