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bp(GO:"spontaneous synaptic transmission")

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Entity

Name
spontaneous synaptic transmission
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

In-Edges 3

p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

It has acute effects on the synapse, serving as an activity-dependent regulator of synaptic plas- ticity and participating in rapid synaptic transmission [150,151,156–159], in the maturation of GABAergic signaling and in the stabilization of newly formed synapses [151,160–163]. PubMed:22040696

Appears in Networks:

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

Treatment with 64627 increases the slope of the I/O curve in both proaggregant Tau transgenic slices and littermate controls (Fig. 5I). PubMed:27671637

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

The slope of the input/output (I/O) curve is significantly reduced in proaggregant Tau transgenic mice compared with controls, indicative of impaired basal synaptic transmission (Fig. 5I) PubMed:27671637

Appears in Networks:
Annotations
MeSH
Mitochondria

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.