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path(MESH:Ischemia)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Ischemia
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) View Subject | View Object

WMH is driven by cerebral small vessel disease, which causes chronic ischemia and increased risk of cognitive decline and dementia (reviewed, (Prins & Scheltens, 2015)) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) View Subject | View Object

NF-κB induction and activation mediates the neuroprotection bestowed by pre-conditioning with a sub-optimal dose of kainic acid and linolenic acid against severe ischemia PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) View Subject | View Object

NF-κB induction and activation mediates the neuroprotection bestowed by pre-conditioning with a sub-optimal dose of kainic acid and linolenic acid against severe ischemia PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

path(HP:"Abnormality of blood circulation") increases path(MESH:Ischemia) View Subject | View Object

On the other hand, impaired microcirculation in the tissue usually causes local ischemia (circulatory disorders and lack of oxygen in the tissue) and often results in multiple organ failure [31]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:Ischemia) View Subject | View Object

Hemolysis can happen due to ischemia/reperfusion, SCD or β-thalassemia. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

Out-Edges 2

path(MESH:Ischemia) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Hemolysis can happen due to ischemia/reperfusion, SCD or β-thalassemia. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:Ischemia) increases path(MESH:"Multiple Organ Failure") View Subject | View Object

On the other hand, impaired microcirculation in the tissue usually causes local ischemia (circulatory disorders and lack of oxygen in the tissue) and often results in multiple organ failure [31]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.