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p(MGI:Sele)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Sele
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

a(CHEBI:heme) positiveCorrelation p(MGI:Sele) View Subject | View Object

Free heme is lipophilic and intercalates into the membrane of endothelial cells increasing vascular permeability and ICAM-1, VCAM-1, and E-selectin expression (19). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

p(MGI:Tlr4) increases p(MGI:Sele) View Subject | View Object

TLR4 401 activation by free heme would induce mobilization of P-selectin and von Willebrand 402 factor to the endothelial surface that triggers VCAM-1, ICAM-1, and E-selectin403 dependent hemostasis and vasoocclusion (3, 4). PubMed:28314763

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

Out-Edges 1

p(MGI:Sele) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Free heme is lipophilic and intercalates into the membrane of endothelial cells increasing vascular permeability and ICAM-1, VCAM-1, and E-selectin expression (19). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.