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complex(a(CHEBI:heme), p(HGNC:ALB))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

a(CHEBI:"adenosine triphosphate") positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

In contrast, less ATP depletion was observed during exposure to heme-albumin, and no effect could be detected when either cell type was exposed to metHb or oxyHb at concentrations of up to 500 lmolL1, even in the absence of serum. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Human Umbilical Vein Endothelial Cells
Text Location
Results

bp(GO:"cellular respiration") positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

This experiment demonstrated that under serum-free conditions, 4 hours of exposure to NaOH-dissolved heme induced complete deterioration of mitochondrial respiration at concentrations as low as 10 lmolL1, while exposure to albumin-associated heme in the presence of 2% FCS stimulated respiratory capacity to levels above baseline. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Mitochondria
Text Location
Results

bp(GO:"inflammatory response") negativeCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

However, similar to Hb, heme-albumin did not induce an inflammatory response in macrophages or endothelial cells in the presence of low concentrations of serum. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Mitochondria
Text Location
Discussion

p(HGNC:HMOX1) positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

In endothelial cells, we found that, in the absence of serum, heme-albumin triggered a dose-dependent HMOX1 protein expression signal in an exposure range of 0–175 lmolL1. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

p(HGNC:HMOX1) positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

heme-albumin is also a robust inducer of dose-dependent HMOX1 expression in BMDMs (Figure 2D). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

p(HGNC:HMOX1) positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

heme-albumin, in contrast, induced HMOX1 in a dose-dependent manner. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

Out-Edges 9

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

In endothelial cells, we found that, in the absence of serum, heme-albumin triggered a dose-dependent HMOX1 protein expression signal in an exposure range of 0–175 lmolL1. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(HGNC:ALB)) hasComponent p(HGNC:ALB) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation a(CHEBI:"adenosine triphosphate") View Subject | View Object

In contrast, less ATP depletion was observed during exposure to heme-albumin, and no effect could be detected when either cell type was exposed to metHb or oxyHb at concentrations of up to 500 lmolL1, even in the absence of serum. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Human Umbilical Vein Endothelial Cells
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation bp(GO:"cellular respiration") View Subject | View Object

This experiment demonstrated that under serum-free conditions, 4 hours of exposure to NaOH-dissolved heme induced complete deterioration of mitochondrial respiration at concentrations as low as 10 lmolL1, while exposure to albumin-associated heme in the presence of 2% FCS stimulated respiratory capacity to levels above baseline. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Mitochondria
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

heme-albumin is also a robust inducer of dose-dependent HMOX1 expression in BMDMs (Figure 2D). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

heme-albumin, in contrast, induced HMOX1 in a dose-dependent manner. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) negativeCorrelation bp(GO:"inflammatory response") View Subject | View Object

However, similar to Hb, heme-albumin did not induce an inflammatory response in macrophages or endothelial cells in the presence of low concentrations of serum. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Mitochondria
Text Location
Discussion

complex(a(CHEBI:heme), p(HGNC:ALB)) increases act(a(CHEBI:"hydrogen peroxide")) View Subject | View Object

Monzani et al. [10] also concluded that the heme-SA complex promotes H2O2 activation processes that bear the characteristics of enzymatic reactions and may have biological relevance. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.