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a(HP:"glymphatic system")

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Entity

Name
glymphatic system
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 4

p(HGNC:AQP4) increases a(HP:"glymphatic system") View Subject | View Object

Unfortunately, the glymphatic system may be impaired due to the loss of AQP4 after traumatic brain injury (Iliff et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:AQP4) increases a(HP:"glymphatic system") View Subject | View Object

It has been reported that ISF tau can be eliminated by the glymphatic system and the function of this clearance mechanism may be impaired due to the loss of AQP4 after TBI, which ultimately accelerates tau accumulation (Iliff et al.2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Extracellular Fluid

path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") View Subject | View Object

Unfortunately, the glymphatic system may be impaired due to the loss of AQP4 after traumatic brain injury (Iliff et al. 2014) PubMed:29626319

Appears in Networks:

path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") View Subject | View Object

It has been reported that ISF tau can be eliminated by the glymphatic system and the function of this clearance mechanism may be impaired due to the loss of AQP4 after TBI, which ultimately accelerates tau accumulation (Iliff et al.2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Extracellular Fluid

Out-Edges 2

a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") View Subject | View Object

In the meanwhile, a study supported this idea that AQP4 deficiency can reduce the rate of Aβ clearance via glymphatic pathway (Iliff and Nedergaard 2013) PubMed:29626319

Appears in Networks:

a(HP:"glymphatic system") decreases p(HGNC:MAPT) View Subject | View Object

It has been reported that ISF tau can be eliminated by the glymphatic system and the function of this clearance mechanism may be impaired due to the loss of AQP4 after TBI, which ultimately accelerates tau accumulation (Iliff et al.2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Extracellular Fluid

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.