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  3. complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)"))

complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)"))

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Components

Appears in Networks 1

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1

In-Edges 1

a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) View Subject | View Object

Removal of N-sulfates or 2-O-sulfates had little effect on tau binding (15.0 ± 5 nM and 7.4 ± 1.0 nM, respectively), while removal of all O-sulfates and, in particular 6-O-sulfates, led to a significant decrease in tau binding (>1 μM in each case; Fig. 3c,d) PubMed:29686391

Appears in Networks:

Out-Edges 3

complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) hasComponent a(HBP:"6-O-sulfated heparin") View Subject | View Object

Appears in Networks:

complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") View Subject | View Object

Removal of N-sulfates or 2-O-sulfates had little effect on tau binding (15.0 ± 5 nM and 7.4 ± 1.0 nM, respectively), while removal of all O-sulfates and, in particular 6-O-sulfates, led to a significant decrease in tau binding (>1 μM in each case; Fig. 3c,d) PubMed:29686391

Appears in Networks:

complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) hasComponent a(HBP:"Tau isoform F (441 aa)") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.