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path(MESH:Malaria)

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Entity

Name
Malaria
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:heme) positiveCorrelation path(MESH:Malaria) View Subject | View Object

The consequences of heme toxicity can be appreciated in hemolytic diseases such as β-thalassemia, sickle-cell disease (SCD), ischemia-reperfusion (IR), and malaria (Katori et al., 2002; Pamplona et al., 2007;Vinchi et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

a(HM:"erythrocyte-endothelium adhesion") positiveCorrelation path(MESH:Malaria) View Subject | View Object

The most common pathological states in which RBCs interact with the endothelium include sickle cell disease [39], malaria [40], and diabetes [41]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(MESH:Plasmodium) positiveCorrelation path(MESH:Malaria) View Subject | View Object

Hemoglobin is used as a nutrient by Plasmodium, the protozoan parasite that causes malaria, during its replication stage inside erythrocytes in the course of the infection in mammals (Francis et al., 1997). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

bp(GO:"complement activation") association path(MESH:Malaria) View Subject | View Object

Indeed, the severe forms of malaria are associated with activation of the complement system [74]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

Out-Edges 5

path(MESH:Malaria) positiveCorrelation a(CHEBI:heme) View Subject | View Object

The consequences of heme toxicity can be appreciated in hemolytic diseases such as β-thalassemia, sickle-cell disease (SCD), ischemia-reperfusion (IR), and malaria (Katori et al., 2002; Pamplona et al., 2007;Vinchi et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Malaria) positiveCorrelation a(MESH:Plasmodium) View Subject | View Object

Hemoglobin is used as a nutrient by Plasmodium, the protozoan parasite that causes malaria, during its replication stage inside erythrocytes in the course of the infection in mammals (Francis et al., 1997). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

path(MESH:Malaria) increases path(MESH:Hemolysis) View Subject | View Object

Systemic hemolysis occurs during certain genetic and acquired anemia, such as in sickle cell disease and malaria. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

path(MESH:Malaria) association bp(GO:"complement activation") View Subject | View Object

Indeed, the severe forms of malaria are associated with activation of the complement system [74]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

path(MESH:Malaria) positiveCorrelation a(HM:"erythrocyte-endothelium adhesion") View Subject | View Object

The most common pathological states in which RBCs interact with the endothelium include sickle cell disease [39], malaria [40], and diabetes [41]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.